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OSE Immunotherapeutics Announces Issuance of a European Patent Protecting FR104, CD28-Antagonist Immunotherapy
The patent covers therapeutic applications of FR104 in Europe in autoimmune diseases, chronic inflammatory diseases and graft applications through 2031
NANTES, France, Sept. 11, 2018 (GLOBE NEWSWIRE) -- OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnémo: OSE), has strengthened its intellectual property rights for the developmental product FR104 through the granting of a patent by the European Patent Office (EPO).
More specifically, this European patent is related to a patent family of FR104 covering its therapeutic applications in T lymphocyte mediated autoimmune diseases, chronic inflammatory diseases and graft applications.
FR104 and its applications are already protected by patents in Japan and in the U.S. The extension to Europe significantly consolidates the product’s intellectual property and value.
“Following the patents in the U.S. and Japan, this allowance from the EPO significantly strengthens the patent protection of FR104 and reinforces its position as a key product in our autoimmune diseases portfolio,” commented Alexis Peyroles, CEO of OSE Immunotherapeutics.
FR104 is a monoclonal antibody and an antagonist of CD28. This pegylated monovalent antibody selectively inhibits the CD28 receptor and has potential clinical applications in autoimmune diseases and transplantation. Phase 1 clinical results showed that FR104 has a strong clinical and biological safety profile and immunosuppressive activity in humans. FR104 is currently licensed to Janssen Biotech to pursue the product’s clinical development.
ABOUT OSE Immunotherapeutics
OSE Immunotherapeutics is a clinical-stage biotechnology company focused on developing and partnering therapies to control the immune system for immuno-oncology and autoimmmune diseases. Neoepitopes innovation (Tedopi®) is today in Phase 3 in advanced lung cancers (NSCLC) after checkpoint inhibitors failure (anti PD-1 and anti PD-L1). A global license and collaboration agreement was signed in April 2018 with Boehringer Ingelheim to develop checkpoint inhibitor OSE-172 (anti-SIRPa monoclonal antibody), for the treatment of advanced solid tumors. An option to license was exercised in July 2016 by Janssen Biotech to continue clinical development of FR104 (an anti CD28 mAb) in auto-immune diseases after positive phase 1 results. A 2-step license option was signed in 2016 with Servier Laboratories to develop OSE-127 (monoclonal antibody targeting the CD127 receptor, the alpha chain of the interleukin-7 receptor) to develop the product up to the completion of a phase 2 clinical trial planned in autoimmune bowel disease; in parallel, Servier plans a development in the Sjogren’s syndrome. The company has several scientific and technological platforms: neoepitopes, agonist or antagonist monoclonal antibodies, ideally positioned to fight cancer and autoimmune diseases. Its first-in-class clinical portfolio offers a diversified risk profile.
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This press release contains express or implied information and statements that might be deemed forward-looking information and statements in respect of OSE Immunotherapeutics. They do not constitute historical facts. These information and statements include financial projections that are based upon certain assumptions and assessments made by OSE Immunotherapeutics’ management in light of its experience and its perception of historical trends, current economic and industry conditions, expected future developments and other factors they believe to be appropriate.
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This press release includes only summary information and should be read with the OSE Immunotherapeutics Reference Document filed with the AMF on 26 April 2018, including the annual financial report for the fiscal year 2017, available on the OSE Immunotherapeutics’ website.
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