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Enesi Pharma and University of Oxford Collaborate to Target Plague With a Novel ImplaVax®-enabled Adenovirus-based Solid Dose Vaccine

OXFORD, England, April 9, 2019 /PRNewswire/ -- Enesi Pharma ("Enesi"), an innovative pharmaceutical company developing unique injectable solid dose drug-device vaccine products and scientists at the world-renowned Oxford Vaccine Group ("OVG") at the University of Oxford, announce they have entered into a collaborative agreement to create and test a solid dose vaccine against plague. The collaboration will leverage Enesi's ImplaVax® needle-free technology and a proprietary vaccine against the bacteria causing plague (Yersinia pestis) developed by OVG, based on a ChAdOx adenovirus vector.

Plague is a serious infectious disease with a high mortality rate unless treated early with antibiotics. There is no approved vaccine available.

According to the World Health Organization, most cases of plague since 1990 have occurred in Africa (particularly in Madagascar), however, outbreaks have been reported worldwide including in the United States. Plague is recognised by public health authorities globally as a potential agent of bioterrorism with Y. pestis classed as a Category A priority pathogen by the US National Institute of Allergy and Infectious Disease (NIAID) and considered a priority pathogen by the UK Vaccine Network based on the high risk that plague poses to national security and public health.

The collaboration between Enesi and OVG aims to create a stable and easy-to-use solid dose plague vaccine for use in areas around the world where outbreaks occur as well as for building strategic stockpiles as part of government preparedness for rapid deployment in the event of a bioterrorism incident.

David Hipkiss, Enesi CEO, commented:

"We are thrilled to enter this new collaboration with Professor Christine Rollier and the University of Oxford. This is our first collaboration to develop vaccines for infectious diseases based on adenovirus vectors and represents important progress with our broad strategy to assess the potential of our ImplaVax technology with the major immunogenic platforms on which global vaccines are based. Plague is a clear priority for governments and public health organisations around the world and there is a real need for a vaccine where none currently exists. We look forward to advancing this exciting project with OVG and benefiting from their insight to the requirements for successful vaccine development."

Professor Christine Rollier at the Oxford Vaccine Group, University of Oxford, added:

"Vaccination represents a foundation of healthcare globally and our goal at OVG is to apply innovation to ensure people are protected from serious but preventable diseases wherever they live. We are pleased therefore that the collaboration with Enesi, through ImplaVax and solid dose vaccines, potentially offers an approach that could help address this challenge."

ImplaVax® is a novel formulation and needle-free device technology that enables solid dose vaccine implants to be delivered quickly under the skin. The aim of the technology is for healthcare providers or individuals themselves to administer the vaccine using this simple, convenient and reusable needle-free device. ImplaVax® also has the potential to generate improved immune responses, and implants benefit from extended thermal stability, which can make a significant contribution to reducing the end-to-end cold chain logistical challenges and distribution costs.

Abbreviation: ChAdOx - chimpanzee adenovirus Oxford


About the Oxford Vaccine Group, University of Oxford

The Oxford Vaccine Group (OVG) conducts studies of new and improved vaccines for adults and children against diseases including meningococcus, pneumococcus, RSV, influenza, typhoid and paratyphoid. The group is based in the Department of Paediatrics in the University of Oxford at the Oxford Vaccine Centre, Churchill Hospital.

The Oxford Vaccine Group has enrolled over 100,000 children and young people into clinical trials over the past two decades to study immunisation. The laboratory research programme has used the clinical material provided by the clinical trials group to drive a series of projects evaluating the developing immune system in the infant.

About Enesi Pharma

Enesi Pharma is an innovative pharmaceutical company developing new products with potential to transform performance and delivery of vaccines and make a material impact on global healthcare.

The company's primary focus is the development of novel solid dose vaccines against a range of infectious and other select diseases, working in partnership with global companies, government agencies and non-governmental organisations.

Enesi's ImplaVax® formulation and device technologies offer significant potential benefits for patients, care givers, healthcare professionals and payers through enhanced effectiveness, safety, ease of use, reliability and stability, and are supported by a strong patient preference over a standard needle and syringe.

The Company has established multiple collaborations to evaluate opportunities for ImplaVax®-enabled vaccines for a range of infectious diseases and allergies, including with the Walter Reed Army Institute of Research, Public Health England, Sementis and GeoVax.

Enesi's experienced leadership team has a proven track record in the successful development and commercialisation of innovative products delivering high value outcomes for all stakeholders. For more information visit or follow Enesi on Twitter at


Enesi Pharma
David Hipkiss, CEO
Tel: +44 (0) 7968 707072

Citigate Dewe Rogerson
Mark Swallow, Pip Batty, Nathaniel Dahan
Tel: +44 (0) 20 7638 9571