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AIT Therapeutics Presented Its High-Dose Nitric Oxide In Vitro Data at the North American Cystic Fibrosis Conference
GARDEN CITY, N.Y. and REHOVOT, Israel, Oct. 18, 2018 (GLOBE NEWSWIRE) -- AIT Therapeutics, Inc. (OTCQB: AITB), a clinical-stage medical device and biopharmaceutical company focused on developing inhaled Nitric Oxide (NO) for the treatment of patients with respiratory conditions including serious lung infections and pulmonary hypertension, today presented a poster with data on high-dose in vitro inhaled NO at the North American Cystic Fibrosis Conference, being held October 18-20 in Denver, CO.
The poster, entitled: “High-Dose Inhaled Nitric Oxide as a Potential Therapy Against Mycobacterial Abscessus Infection in Cystic Fibrosis,” demonstrated the activity of high-dose NO against various multidrug-resistant clinical isolates of M. abscessus in vitro. Several multidrug-resistant clinical isolates of M. abscessus showed significant susceptibility to 250 ppm NO treatment. Even though the high-dose NO kill rate was not uniform across all M. abscessus strains, none of the clinical isolates were resistant to NO monotherapy. Future studies are being planned to assess NO activity in combination with commonly used antibiotics for NTM lung infection.
The poster can be accessed on the company website at www.AIT-PHARM.com.
“MABSC is a devastating and debilitating disease with no currently approved therapy. We are pleased to present data that show NO treatment as a potential meaningful therapy in these patients,” said Steven Lisi, Chairman and Chief Executive Officer of AIT Therapeutics. “We look forward to showing further in vitro data in the near future in combination with antibiotics commonly used to treat NTM as we believe we can identify an optimal combination treatment.”
About Nitric Oxide (NO)
Nitric Oxide (NO) is a powerful molecule proven to play a critical role in a broad array of biological functions. In the airways, NO is believed to play a key role in the innate immune system at concentrations of approximately 200 ppm. In vitro studies suggest that NO possesses anti-microbial activity not only against common bacteria, both gram-positive and gram-negative, but also against other diverse organisms including mycobacteria, fungi, yeast and parasites, and has the potential to eliminate multi-drug resistant strains.
About Mycobacterium abscessus complex (MABSC) of the Lungs
MABSC is the most aggressive and difficult to treat species of nontuberculous mycobacteria (NTM). There are currently no approved treatments for MABSC. Current standard-of-care is a cocktail of antibiotics that often proves to be ineffective with severe adverse effects. Most patients suffering from MABSC have an underlying disease, such as cystic fibrosis or chronic obstructive pulmonary disease (COPD). The median survival of those suffering from MABSC is less than 5 years.
About AIT Therapeutics Inc.
AIT Therapeutics Inc. is a clinical-stage medical device and biopharmaceutical company using nitric oxide (NO) to treat respiratory and other diseases. The Company is currently applying its therapeutic expertise to treat lower respiratory tract infections that are not effectively addressed with current standards of care, as well as pulmonary hypertension, in various settings. AIT is currently advancing its revolutionary NO Generator and Delivery System in clinical trials for the treatment of bronchiolitis and severe lung infections such as nontuberculous mycobacteria (NTM). For more information, visit www.AIT-Pharm.com.
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Steven Lisi, Chief Executive Officer
AIT Therapeutics, Inc.
LifeSci Advisors, LLC