You are here

Lynparza Improves Progression-Free Survival in Pancreatic Cancer Patients

22% of Patients Progression-Free Two Years Later

Results from the POLO trial demonstrate that patients treated with olaparib (Lynparza, AstraZeneca and Merck & Co., Inc.) compared with placebo had statistically significant and clinically meaningful improvement in progression-free survival (median, 7.4 months vs. 3.8 months, respectively). In addition, more than twice the number of patients showed no disease progression at one year (34% on olaparib vs. 15% on placebo) and at two years (22% vs. 10%, respectively).

Pancreatic cancer is the 12th most common cancer worldwide, and has the worst survival rate among the most common cancers. Early diagnosis is difficult as symptoms usually manifest in late stages, and approximately 80% of patients are diagnosed at the metastatic stage. Fewer than 3% of patients with metastatic pancreatic cancer survive more than five years after diagnosis.

Olaparib’s safety and tolerability profile was similar to that observed in prior clinical trials. The most common adverse events were fatigue/asthenia (60%), nausea (45%), abdominal pain (29%), diarrhea (29%), anaemia (28%), decreased appetite (25%) and constipation (23%).

The phase 3 randomized, double-blinded, placebo-controlled, multicenter POLO trial compared olaparib tablets as maintenance monotherapy versus placebo in 154 patients with gBRCAm metastatic pancreatic cancer whose disease had not progressed on first-line platinum-based chemotherapy. Patients were randomized (3:2) to olaparib or placebo until disease progression. The primary endpoint was progression-free survival, and key secondary endpoints included overall survival, time to second disease progression, overall response rate, disease control rate, and health-related quality of life.

Olaparib is a first-in-class PARP inhibitor and the first targeted treatment to block DNA damage response (DDR) in cells/tumors harboring a deficiency in homologous recombination repair (HRR), such as mutations in BRCA1 and/or BRCA2.

Source: AstraZeneca, June 3, 2019

Recent Headlines

Study of posted prices finds wild variations and missing data
Potential contamination could lead to supply chain disruptions
Despite older, sicker patients, mortality rate fell by a third in 10 years
Study finds fewer than half of trials followed the law
WHO to meet tomorrow to decide on international public heath emergency declaration
Declining lung cancer mortality helped fuel the progress
Kinase inhibitor targets tumors with a PDGFRA exon 18 mutation
Delayed surgery reduces benefits; premature surgery raises risks
Mortality nearly doubled when patients stopped using their drugs