You are here

Second Trial of CTP-692 for Schizophrenia Underway

Drug Could Treat Cognitive Dysfunction and Other Symptoms

Concert Pharmaceuticals, Inc. has begun the second phase 1, single-ascending dose trial with CTP-692, a novel deuterium-modified form of D-serine being developed as an adjunctive treatment for schizophrenia.

CTP-692 is a deuterium-modified analog of endogenous D-serine. It may have the potential to restore NMDA receptor activity in key parts of the brain, thus improving clinical outcomes in patients with schizophrenia.

The initial phase 1 trial, conducted in Australia, evaluated the safety, tolerability, and pharmacokinetics of a single oral dose of CTP-692 versus D-serine. In patients treated with both compounds, CTP-692 increased plasma exposure compared to D-serine. Further, the drug was well tolerated in healthy volunteers and no serious adverse events were reported.

Under an investigational new drug application in the U.S., Concert will evaluate the safety, tolerability, and pharmacokinetics of single-ascending oral doses of CTP-692 in a double-blind, placebo-controlled trial. The trial will also assess the effect of food on the drug’s pharmacokinetics, and will include a study assessing CTP-692 dosed orally over seven days. Topline data is expected by mid-2019.

Source: Seeking Alpha, January 24, 2019

Recent Headlines

Despite older, sicker patients, mortality rate fell by a third in 10 years
Study finds fewer than half of trials followed the law
WHO to meet tomorrow to decide on international public heath emergency declaration
Study of posted prices finds wild variations and missing data
Potential contamination could lead to supply chain disruptions
Delayed surgery reduces benefits; premature surgery raises risks
Mortality nearly doubled when patients stopped using their drugs
Acasti reports disappointing results for a second Omega-3-based drug
Declining lung cancer mortality helped fuel the progress