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Antidepressants Linked to Elevated Death Risk, Study Finds

Such drugs often block the serotonin that other organs need

Antidepressant medications, most commonly prescribed to reduce depression and anxiety, increase the risk of death, according to findings from researchers at McMaster University.

It’s widely known that brain serotonin affects mood and that most commonly used antidepressant treatment for depression blocks the absorption of serotonin by neurons. It is less widely known, though, that all the major organs of the body—the heart, kidneys, lungs, and liver—use serotonin from the bloodstream. Antidepressants block the absorption of serotonin in these organs as well, and the researchers warn that antidepressants could increase the risk of death by preventing multiple organs from functioning properly.

The researchers reviewed studies involving hundreds of thousands of people and found that antidepressant users had a 33% higher chance of death than nonusers. Antidepressant users also had a 14% higher risk of cardiovascular events, such as strokes and heart attacks.

“We are very concerned by these results. They suggest that we shouldn’t be taking antidepressant drugs without understanding precisely how they interact with the body,” author Paul Andrews, an associate professor at McMaster University who led the research team, said in a press release.

Taken by one in eight adult Americans, antidepressants are among the most frequently used medications. They are often prescribed by family doctors without a formal diagnosis of depression, on the assumption that they are safe. Because depression itself can be deadly—people with depression are at an increased risk of suicide, stroke, and heart attack—many physicians think that antidepressants could save lives by reducing depressive symptoms.

However, McMaster researcher and coauthor Marta Maslej said, "Our findings are important because they undermine this assumption. I think people would be much less willing to take these drugs if they were aware how little is known about their impact outside of the brain, and that what we do know points to an increased risk of death."

Benoit Mulsant, a psychiatrist at the University of Toronto who was also involved in the study, said the findings point to the need for more research on how antidepressants actually do work.

“I prescribe antidepressants even though I do not know if they are more harmful than helpful in the long term. I am worried that in some patients they could be, and psychiatrists in 50 years will wonder why we did not do more to find out,” Mulsant said.

Interestingly, the news about antidepressants is not all bad. The researchers found that antidepressants are not harmful for people with cardiovascular diseases and diabetes. This makes sense because these antidepressants have blood-thinning effects that are useful in treating such disorders. Unfortunately, this also means that for most people who are in otherwise good cardiovascular health, antidepressants tend to be harmful.

The findings were published in the journal Psychotherapy and Psychosomatics.

Source: McMaster University; September 15, 2017.

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