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Scientists Use Tiny Gold Rods to Relieve Intractable Pain

Heated nanorods target pain receptors

A team of scientists at Kyoto University in Japan has developed a novel technique using tiny gold rods to target pain receptors.

Gold nanorods are tiny rods that are 1 to 100 nanometers wide. In comparison, a human hair is 100,000 nanometers wide.

The researchers coated the nanorods with a lipoprotein that transports fat in the body. This allowed the rods to bind efficiently to nerve-cell membranes bearing a pain receptor called TRPV1 (transient receptor potential vanilloid type 1). Near-infrared light was then applied to the nanorod-coated pain receptors. The nanorods heated up, activating the pain receptors to allow an influx of calcium ions through the membrane.

Prolonged activation of TRPV1 is known to lead to their desensitization, bringing pain relief. Importantly, heating the gold nanorods enabled safe activation of the TRPV1 pain receptors alone, without affecting the membrane in which they lie, the researchers say.

Previous studies had shown that magnetic nanoparticles (tiny particles in the nano-range made out of magnetic materials) are also able to activate TRPV1 receptors by applying a magnetic field. The target cells, however, require genetic modification for this method to work. Using lipoprotein-coated gold nanorods does not require genetic modification of the target cells. In addition, the nanorods were found to have at least 1,000 times greater efficiency than magnetic nanoparticles in heat generation and in activating TRPV1 receptors.

“The gold nanorods can be retained in the body for a prolonged period,” principal investigator Dr. Tatsuya Murakami. “Local injection of our gold nanorods might enable repetitive and on-demand treatment for people experiencing intractable pain because prior genetic engineering of the target cells is unnecessary.”

The study was published on August 6 in the international edition of Angewandte Chemie.

Source: EurekAlert; August 21, 2015.

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