You are here

Natural, Edible Treatment Offers Promise for Diabetics

Oral capsule mimics benefits of major surgery (June 27)

The American Heart Association (AHA) is investing in an oral treatment that delivers natural substances, dramatically improving blood sugar levels in diabetics. According to the AHA, this investment holds the promise of replacing synthetic drugs for thousands of type-2 diabetics.

Morbidly obese diabetics often undergo intestinal bypass surgery to lose weight. The surgery shortens the small intestine so that just a fraction of calories ingested have time to be absorbed in the small intestine before reaching the colon, where waste is handled. These diabetics appear virtually “cured” of their diabetes before they leave the operating room.

The likely reason, the AHA says, is that two nutrients in everyone’s diet, sodium butyrate and L-glutamine, are normally absorbed shortly after they leave the stomach, but they reach the colon after gut-shortening surgery. The colon has receptors that bind with them, causing a massive increase in insulin secretion and a decrease in insulin resistance.

Non-obese diabetics are not candidates for intestinal bypass surgery, but researchers have found a way to create an “artificial short gut” with a capsule that delivers these nutrients from mouth to colon, lowering blood glucose to normal.

“The patients’ blood glucose is normalized before they’ve lost an ounce. It appears, in many of them, as if they never had diabetes in the first place,” said cardiologist Ross Tonkens, MD.

“Many diabetics could be moved from prosthetic drugs — which the FDA is scrutinizing for toxicities, including increasing the incidence of pancreatic cancer — to natural substances with no toxicities,” Tonkens said. “The implications are huge.”

Source: AHA; June 27, 2013.

Recent Headlines

Disrupting Gut Microbiome Could Be Key
Drug Boosts Levels of Natural Endocannabinoids
Judicious Use of Antibiotics May Not Be Enough To Defeat Bacteria That Carry On By Going Into a Dormant State
KRAS Oncogene Is a Problematic Target So Researchers Are Trying Workdarounds
Understanding Neural Ensembles in Infralimbic Cortex May Lead To Improved Addiction Treatment
Vitamin E Found in Samples Around the Country
Study Links Them to Premature Death
Nag With Texting and a ‘Winners Circle’
How Serotonin and Fluoxetine Affect Microbiota Residing in the Gut