You are here

Researchers Discover Gene That Permanently Stops Cancer Cell Proliferation

The study was published in Cancer Research.

While investigating the basic mechanisms of genome integrity, the research team unexpectedly discovered an active mutant form of human Chk1, which is also a non-natural form of this gene. This mutation changed the protein conformation of Chk1 from the inactive form into an active form. The researchers discovered that, when expressed in cancer cells, this active mutant form of Chk1 permanently stopped cancer cell proliferation and caused cell death in petri dishes without the addition of chemotherapeutic drugs.

Future research at the School will consider two possible approaches to artificially activating Chk1 in cancer cells. One possibility is to deliver the active mutant form of Chk1 into cancer cells. The other possibility is to search for small molecules that can induce the same conformational change in Chk1 genes, so that the genes can be delivered into cancer cells to activate Chk1 molecules. Theoretically, the consequence of either approach would be the permanent inhibition of cell proliferation and cancer.

For more information, read the Case Western University news release.

Recent Headlines

Scenesse is new treatment for people with rare, painful light sensitivity disease
Humira, Rituxan top list of drugs that added $5.1 billion to nation's health care bill
Lower court rulings cleared the way for generic versions of the MS drug
Maryland man wins lawsuit that alleges that the company's antipsychotic caused his gynecomastia
Antidepressants, ADHD meds are also used to self-poison
Study lists steps that could save close to $300 billion a year
While many victims used THC, the cause remains elusive
Descovy joins Truvada, another Gilead product, in the HIV prophylaxis market
Data show PTC Therapeutics drug preserves lung function