You are here
Choosing Bacteria-Killing vs. Bacteria-Inhibiting Drugs in Treating Infections
In central nervous system infections, a rapidly bactericidal drug can release bacterial products that stimulate inflammation. For this reason, it is recommended that corticosteroids be given at the same time as a bactericidal antibiotic for bacterial meningitis. Certain bacteriostatic drugs may be preferable in cases of streptococcal and clostridial gangrene, because they inhibit the production of the toxins that cause much of the morbidity.
Some infectious disease physicians wrongly believe that bacteria-killing drugs are automatically preferable to those that inhibit bacterial growth, according to Dr. Robert Finberg, of the University of Massachusetts, lead author of the study. "The misperception that it's always better to use a bactericidal drug is incorrect," said Dr. Finberg.
"It's probably important to use bactericidal drugs in treating endocarditis and meningitis," Dr. Finberg added, "but in many situations, cidal drugs are not preferable over static drugs."
Source: Infectious Disease Society of America