The addition of black-box warnings to antidepressants may have led to unintended consequences, including a decline in diagnosis and treatment for depression and perhaps even an end to decreasing rates of suicide.
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P&T® Journal contents for July 2009
A Public Health Experiment with Unintended Consequences?
Patients with type-2 diabetes face a high risk of heart disease. Although insulin, sulfonylureas, metformin, and thiazolidinediones (TZDs) help with glycemic control, caution is needed when these agents are prescribed for patients with existing cardiovascular disease.
Some of the topics covered at the ASCO sessions included therapies for gastro-intestinal tumors; gastric cancer; chronic myeloid leukemia; advanced melanoma, metastatic breast cancer; and ovarian, fallopian, and peritoneal cancer. A comparison of the effects of letrozole (Femara) and tamoxifen (Nolvadex) on cognitive function in patients with postmenopausal breast cancer is also presented.
Topics include iloperidone (Fanapt) for the acute treatment of schizophrenia; bromocriptine mesylate tablets (Cycloset) for glycemic control in type-2 diabetes; and tolvaptan (Samsca) for patients with hyponatremia.
An evaluation of electronic medical records was undertaken to determine whether optimal prophylactic therapy was being provided for HIV-infected patients with Pneumocystis pneumonia.