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P&T® Journal contents for July 2009


Literature Review
A Public Health Experiment with Unintended Consequences?
The addition of black-box warnings to antidepressants may have led to ­unintended consequences, including a decline in diagnosis and treatment for depression and perhaps even an end to decreasing rates of suicide.
Jack Alan McCain
Patients with type-2 diabetes face a high risk of heart disease. Although insulin, sulfonylureas, metformin, and thiazolidinediones (TZDs) help with glycemic ­control, caution is needed when these agents are prescribed for patients with existing cardiovascular disease.
Erin L. St. Onge, PharmD, Carol Anne Motycka, PharmD, and Shannon A. Miller, PharmD
Meeting Highlights
Some of the topics covered at the ASCO sessions included therapies for gastro­-intestinal tumors; gastric cancer; chronic myeloid leukemia; advanced melanoma, metastatic breast cancer; and ovarian, fallopian, and peritoneal cancer. A com­parison of the effects of letrozole (Femara) and tamoxifen (Nolvadex) on ­cognitive function in patients with postmenopausal breast cancer is also ­presented.
Walter Alexander
Topics include iloperidone (Fanapt) for the acute treatment of schizophrenia; bromocriptine mesylate tablets (Cycloset) for glycemic control in type-2 diabetes; and tolvaptan (Samsca) for patients with hyponatremia.
Marvin M. Goldenberg, PhD, RPh, MS
P&T Snapshot
An evaluation of electronic medical records was undertaken to determine whether optimal prophylactic therapy was being provided for HIV-infected patients with Pneumocystis pneumonia.
Amesh A. Adalja, MD, and Emanuel N. Vergis, MD, MPH


David B. Nash, MD, MBA, discusses the “ergonomics of innovation,” encouraging organizations to create something new from existing ideas, breaking down goals into manageable pieces, and ­making it easier to promote change.
David B. Nash, MD, MBA
Medication Errors
More Protection Needed for Patients and Their Families
Matthew Grissinger, RPh, FASCP, explains how patients can prevent accidental exposure to and misuse of fentanyl transdermal patches.
Matthew Grissinger, RPh, FASCP
Prescription: Washington
Stephen Barlas discusses the potential impact of “consumer-centric” and public interest attitudes on health care reform in the Obama administration.
Stephen Barlas
From Besivance eyedrops to the Qutenza patch, P&T presents the latest studies about FDA approvals, new indications, recalls, and industry updates.