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P&T® Journal contents for February 2008
Use and Outcomes of Antifibrinolytic Therapy in Patients Undergoing Cardiothoracic Surgery at 20 Academic Medical Centers in the United States
Given the association between the use of aprotinin (Trasylol) and an increased risk of adverse events among cardiothoracic surgery patients, in contrast to a lack of elevated risk for aminocaproic acid and tranexamic acid, the authors suggest that hospitals examine their current patterns of use and perhaps restrict aprotinin for these patients to prevent major blood loss.
Evaluation of the Management of Acute Venous Thromboembolism and Its Outcomes: One Institution’s Experience
The authors describe a study in which they sought to determine whether standard practice guidelines for the care of patients with VTE were being followed at their VA center.
Presentations cover lenalidomide (Revlimid) in the treatment of multiple myeloma, eculizumab (Soliris) for paroxysmal nocturnal hemolysis, RAD001 (Everolimus) for lymphoma, the use of deferasirox (Exjade) in patients with iron overload, and dasatinib (Sprycel) and nilotinib (Tasigna) for chronic myelogenous leukemia.
Topics include sapropterin dihydrochloride tablets (Kuvan) for reducing phenylalanine levels in patients with phenylketonuria; nebivolol (Bystolic) for hypertension; and a starch infusion (Voluven) to prevent decreased blood volume during surgery.