Although the use of benzodiazepines has been reported to be associated with hip fractures in the elderly, a 2007 study reveals that no significant reduction in hip fractures resulted when the drugs were restricted. Dr. Kaell and Dr. Freedman suggest that removing this drug class from insurance coverage might not be in the best interest of patients.
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P&T® Journal contents for July 2007
Two new agents—temsirolimus (Torisel) and estradiol (Divigel)—have been approved: temsirolimus for patients with advanced kidney cancer and estradiol for hot flashes associated with menopause. The newest indication for somatropin (rDNA origin) (Norditropin), approved as an injection for treating short stature in children with Noonan’s syndrome, is also discussed.
Advances in reducing symptoms of schizophrenia include a transdermal estrogen patch and an investigational agent, bifeprunox. An integrated approach (home visits and group family sessions) plus standard treatment (contact with a mental health center) also helped to reduce the number of patients with concomitant substance abuse.
The authors report on the efficacy and cost-effectiveness of antiresorptive medications (bisphosphonates, selective estrogen receptor modulators, and calcitonin); anabolic agents (parathyroid hormone); and strontium ranelate, all of which show promise in preventing fractures in women with osteoporosis after menopause.