Erlotinib (Tarceva) for patients with pancreatic cancer; nelarabine (Arranon) injection for leukemia and lymphoma; and sodium oxybate oral solution (Xyrem) for the treatment of narcolepsy are highlighted.
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P&T® Journal contents for January 2006
Dr. Wittbrodt emphasizes the urgent need for effective therapies for prolonged postoperative ileus, which is often associated with increased hospital costs and an extended length of stay for patients.
The Prescotts report on the use of extended-release niacin for dyslipidemic patients with HIV infection, a lipid-lowering combination of fenofibrate/ezetimibe for mixed hyperlipidemia, omega-3 fatty acids for overweight children, low-dose pravastatin for mild hypercholesterolemia, a strategy for women with acute coronary syndrome, low-molecular-weight heparin for ST-segment elevation myocardial infarction (MI), pioglitazone for diabetic patients with previous MIs, and nesiritide and levosimendan (Simdax) for decompensated heart failure.
Advances in treating autism; Alzheimer’s disease; substance abuse; and movement disorders, including Huntington’s disease and Parkinson’s disease, by means of viral vector techniques, are presented.
This month, three of P&T’s editorial board members contribute reviews of books of interest to the health care community: Handbook of Clinically Tested Herbal Remedies, Volumes 1 and 2, by Marilyn Barrett, PhD, Editor, reviewed by Robert L. Barkin, MBA, PharmD; Dictionary of Pharmacy, by Dennis B. Worthen, PhD, Editor-in-Chief, reviewed by F. Randy Vogenberg, RPh, PhD; and Flashback by Gary Braver, reviewed by Art Shinn, PharmD.
F. Randy Vogenberg reviews a new book by Michael P. Cecil, MD, that should be a resource for consumers, health care professionals, and Medicare-eligible beneficiaries despite some complications brought about by the new Medicare Part D regulations.
Health Care and Law
Pennsylvania becomes the newest state in which pharmacists will be playing a larger role in the drug prescription process: they will have the authority to adjust drug regimens, order laboratory and diagnostic tests, and administer medications.
Management of Community-Acquired Respiratory Tract Infections in an Era of Increasing Antibiotic Resistance
The authors discuss the extent of the problem of antibiotic resistance in the U.S., assess the clinical and economic ramifications of such resistance, and provide an overview of antibiotics currently available for the empirical treatment of out-patients with community-acquired RTIs.
Continuing Education Credit
The author reviews the current understanding of the pathophysiology of congestive heart failure (CHF) and discusses the paradigm shift in thinking about the role of beta blockers in CHF management.
Dr. Goldenberg reviews letrozole (Femara) for early breast cancer, lenalidomide (Revlimid) for anemia, and abatacept (Orencia) for rheumatoid arthritis.
Doctors need help in assisting their patients to understand the new Part D rules. Patients need help to avoid being “scammed.” Dr. Stefanacci helps us sort it out.
The authors discuss the appropriate indications of PPIs and focus on the negative ramifications of the widespread and long-term use of these agents.
Topics covered include therapies for multiple myeloma, leukemia, sickle cell disease, and lymphoma.
The authors report on advances in the treatment of maxillary sinusitis, otitis media, skin and skin structure infections, diarrhea, gram-negative bacterial infections, zygomycosis, infectious mononucleosis, and combination therapy for HIV infection
The essays in “Ethics and the Pharmaceutical Industry” address the complex inter relationships between drug companies, clinicians, patients, and advocacy groups.
Dr. Goldenberg reviews cetuximab (Erbitux) combined with radiation therapy for cancer of the head and neck; sunitinib (Sutent) for gastrointestinal stromal tumors (GISTs) and advanced kidney cancer; and sorafenib tosylate (Nexavar) for advanced renal cell carcinoma.
The authors report on advances with morphine sulfate and oxymorphone for back pain, ziconotide for chronic pain, intranasal morphine and transdermal hydromorphone for postoperative pain, fentanyl tablets for cancer-related breakthrough pain, lower-dose epidural steroids for lumbar radiculopathy and spinal stenosis, and duloxetine for diabetic peripheral neuropathic pain.
Letter to the Editor
Continuing Education Credit
The authors discuss the fundamentals of epidemiology in the context of cohort studies, case-control studies, and experimental studies (clinical trials) and describe the importance of epidemiology in making formulary decisions.
Utilization of Health Care Resources in a High-Risk Medicaid Population with Chronic Obstructive Pulmonary Disease
The authors present a study in which they sought to identify patterns of disparities in race and sex in the use of health care resources by Medicaid patients with COPD, a population composed predominantly of minorities, women, and children.