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Drug Class Review

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors In the Management of Diabetes

Rolee Pathak, PharmD, RPh, BCPS; and Mary Barna Bridgeman, PharmD, RPh
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Sitagliptin (Januvia) and saxagliptin (Onglyza) provide another option for type-2 ­diabetes. However, clinicians should consider the cost, the potential for hypoglycemia, and the modest efficacy associated with these agents.