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Expenditures Associated with Dose Titration at Initiation of Therapy in Patients with Major Depressive Disorder

A Retrospective Analysis of a Large Managed Care Claims Database
Fabian Camacho, MS, MA; Meg C. Kong, PhD; David V. Sheehan, MD, MBA; and Rajesh Balkrishnan, PhD
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Although selective serotonin reuptake inhibitors (SSRIs) are considered cost-effective for major depression, dosage adjustments may be necessary when therapy starts. In the authors' study, patients undergoing dose titration of SSRIs used more medical resources and spent more days receiving a subtherapeutic dose than comparable controls not undergoing dose titration.