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Drug Review

Lisdexamfetamine Dimesylate (Vyvanse), A Prodrug Stimulant for Attention-Deficit/Hyperactivity Disorder

David W. Goodman, MD
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As a first-line therapy for adults and children 6 to 12 years of age for ADHD, LDX is associated with a lower daily average use, less need for augmenting the dose, and better persistence with therapy compared with other long-acting drugs. Dr. Goodman reviews the drug’s history, benefits and risks, labeling for abuse potential, adverse events, and overall safety profile.