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Medication Utilization Patterns and Hypertension-Related Expenditures among Patients Who Were Switched from Fixed-Dose To Free-Combination Antihypertensive Therapy

Gregory Hess, MD, MBA; Jerrold Hill, PhD; Helen Lau, MS; Homa Dastani, PhD; and Paresh Chaudhari, PharmD, MPH
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In an evaluation of patients who were switched from fixed-dose combination (FDC) to free-combination (FC) therapy for elevated blood pressure, the authors found that patients continuing with the FDC regimen had better persistence and compliance compared with patients who were switched to FC therapy. Greater compliance with the FDC regimen was also associated with lower health care costs and with less use of health care–related resources.