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Continuing Education Credit

Cardiovascular Effects of COX-2 Inhibitors: A Review of the Literature

Craig D. Cox, PharmD, BCPS, Brad L. Stanford, PharmD, BCOP, James P. Tsikouris, PharmD, Michael J. Peeters, PharmD, BCPS, and Gary Meyerrose, MD
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In multiple trials and analyses, the incidence of cardiovascular events has been higher with coxibs than with placebo and other nonselective NSAIDs. Although an explanation for these events has not yet been determined, several theories relate to physiological mechanisms, drug selectivity or structure, doses and duration of clinical trials, and the influence of underlying disease states.