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Drug Forecast

Perseris: A new, long-acting, atypical antipsychotic drug-delivery system
Andrew Karas PharmD
Gary Burdge PharmD
Jose A. Rey MS, PharmD, BCPP
Shingrix, a new vaccine for herpes zoster
Fraidy Maltz BS, PharmD, BCACP
Brooke Fidler PharmD
Intranasal esketamine for treatment-resistant depression
Rebecca Bahr PharmD Candidate
Alicia Lopez PharmD
Jose A. Rey MS, PharmD, BCPP
Cannabidiol oral solution for seizures associated with Lennox-Gastaut and Dravet syndromes
Dovena Lazaridis PharmD, BCPS
Nathaniel Eraikhuemen PharmD
Kia Williams BS
Judith Lovince
Meropenem-Vaborbactam (Vabomere) for carbapenem-resistant Enterobacteriaceae
Yuman Lee PharmD, BCIDP
Juliette Kim PharmD, BCIDP
Saralinh Trinh PharmD Candidate

Influenza activity during the 2017–2018 season was high, with an estimated 48.8 million people becoming ill, 959,000 hospitalizations and 79,400 deaths. Xofulza (baloxavir marboxil) is a new antiviral agent approved by the FDA on October 24, 2018. This drug forecast article reviews the pharmacology, pharmacokinetics, clinical efficacy, dosage and administration, safety profile, and place in therapy of Xofluza.

Kimberly E. Ng PharmD, BCPS

Steglatro (ertugliflozin) for glycemic control in adults with type-2 diabetes mellitus

Nikolas Kovacich PharmD Candidate
Benjamin Chavez PharmD, BCPP, BCACP
A Novel Fluoroquinolone for the Treatment of Acute Bacterial Skin and Skin Structure Infections

Baxdela (delafloxacin) for treatment of acute bacterial skin and skin structure infections

Alexandra Adler PharmD Candidate
Saira Chaudhry PharmD, MPH
Tamara Goldberg PharmD, BCPS

Naldemedine (Symproic) for opioid-induced constipation

Kenneth Hu PharmD
Mary Barna Bridgeman PharmD, BCPS, BCGP

Etelcalcetide (Parsabiv) for hyperparathyroidism in adults with chronic kidney disease on hemodialysis

Jena Patel PharmD Candidate
Mary Barna Bridgeman PharmD, BCPS, BCGP
The First FDA-Approved Treatment for Tardive Dyskinesia

Valbenazine (Ingrezza): the first FDA-approved treatment for tardive dyskinesia

Stepan Uhlyar PharmD
Jose A. Rey PharmD, BCPP

Olaratumab (Lartruvo): an innovative treatment for soft tissue sarcoma

Lindsey Penniman PharmD
Sapna Parmar PharmD, BCOP
Khilna Patel PharmD, BCOP

Plecanatide (Trulance) for chronic idiopathic constipation and irritable bowel syndrome with constipation

Julia A. Kamuda PharmD Candidate
Nissa Mazzola PharmD, CDE
A New-Generation Lipoglycopeptide for the Treatment Of Acute Bacterial Skin and Skin Structure Infections

Oritavancin (Orbactiv): a new-generation lipoglycopeptide for the treatment of acute bacterial skin and skin structure infections

Samantha Rosenthal PharmD, BCPS
Arnold G. Decano PharmD
Aiman Bandali PharmD
Denise Lai PharmD
A Direct-Acting Oral Anticoagulant Factor Xa Inhibitor

Betrixaban (Bevyxxa): a direct-acting oral anti-coagulant factor Xa inhibitor

Jessica W. Skelley PharmD, BCACP
Angela R. Thomason PharmD, BCPS
Jeffery C. Nolen
PharmD Candidate
A Novel Neuroprotective Agent for the Treatment of Amyotrophic Lateral Sclerosis

Edaravone (Radicava): a novel neuroprotective agent for the treatment of amyotrophic lateral sclerosis

Martin Paspe Cruz PharmD, BCGP, BCPP, FASCP
The First Monoclonal Antibody Approved to Prevent the Recurrence of a Bacterial Infection

Bezlotoxumab (Zinplava) to prevent the recurrence of Clostridium difficile infection

Yuman Lee PharmD, BCPS
Wai I. Lim PharmD
Caitlyn I. Bloom PharmD
Samantha Moore PharmD
A Once-Daily Incretin Mimetic Injection for Type-2 Diabetes

Lixisenatide (Adlyxin), a once-daily incretin mimetic injection for type-2 diabetes

Nicholas Leon PharmD
Richard LaCoursiere PharmD
Deirdre Yarosh MA, PharmD
Roshni S. Patel PharmD
A Monoamine Oxidase B Inhibitor for the Adjunct Treatment of Motor Symptoms in Parkinson’s Disease

Xadago (safinamide), a monoamine oxidase B inhibitor for the adjunct treatment of motor symptoms in Parkinson’s disease

Martin Paspe Cruz PharmD, BCGP, BCPP, FASCP
An Interleukin-5 Antagonist for Severe Asthma of the Eosinophilic Phenotype

Reslizumab (Cinqair), an interleukin-5 antagonist for severe eosinophilic asthma

Selina Hom PharmD Candidate
Michele Pisano PharmD, BCGP, CDE

Probuphine (buprenorphine) subdermal implants for the treatment of opioid-dependent patients

Lillian Smith PharmD, MBA, CPH
Juan Mosley PharmD, CPH, AAHIVP
Jasmine Johnson PharmD
Monica Nasri PharmD
A Mu-Opioid Receptor Agonist for the Treatment Of Irritable Bowel Syndrome With Diarrhea

Eluxadoline (Viberzi) for the treatment of irritable bowel syndrome with diarrhea

Fraidy Maltz PharmD, BCACP
Brooke Fidler PharmD
A Treatment for Hallucinations and Delusions Associated With Parkinson’s Disease

Pimavanserin (Nuplazid) for the treatment of hallucinations and delusions associated with Parkinson’s disease

Martin Paspe Cruz PharmD, BCGP, BCPP, FASCP

Otiprio: an FDA-approved ciprofloxacin suspension gel for pediatric otitis media

Ann L. Edmunds MD, PharmD
The First FDA-Approved Treatment for Female Sexual Interest/Arousal Disorder in Premenopausal Women

Flibanserin (Addyi) for female sexual interest/arousal disorder in premenopausal women

Clayton English PharmD, BCPS, BCPP
Anne Muhleisen PharmD
Jose A. Rey MS, PharmD, BCPP
A Substance P/Neurokinin-1 Receptor Antagonist for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Rolapitant (Varubi) for the prevention of chemotherapy-induced nausea and vomiting

Tamara Goldberg PharmD, BCPS
Brooke Fidler PharmD
Stephanie Cardinale PharmD
A Novel Adjunctive Therapy for Partial-Onset Seizures

Brivaracetam (Briviact): a novel adjunctive therapy for partial-onset seizures

Farbod Khaleghi
Eric C. Nemec PharmD, BCPS

Zarxio (filgrastim-sndz), a biosimilar for the treatment of severe chronic neutropenia

Mina Awad PharmD Candidate
Pavit Singh PharmD Candidate
Olga Hilas PharmD, MPH
A Treatment Option for Chronic Hepatitis C Infection

Daclatasvir (Daklinza) for chronic hepatitis C infection

Maggie Montgomery PharmD
Natalie Ho PharmD
Elizabeth Chung PharmD
Nino Marzella PharmD
A Review of Clinical Efficacy and Safety in Epilepsy

Perampanel (Fycompa): a review of clinical efficacy and safety in epilepsy

Jessica Greenwood MS, PharmD Candidate
Jose Valdes PharmD, BCPP

Mepolizumab (Nucala) for severe eosinophilic asthma

Min Sung Choy PharmD Candidate
Deepali Dixit PharmD, BCPS
Mary Barna Bridgeman PharmD, BCPS, CGP
An Extended-Release, Long-Acting Injection For the Treatment of Schizophrenia

Aripiprazole lauroxil (Aristada) for the treatment of schizophrenia

Martin P. Cruz PharmD, CGP, BCPP, FASCP
For the Treatment of Complicated Intra-Abdominal and Urinary Tract Infections

Ceftazidime-avibactam (Avycaz) for the treatment of complicated infections

Juan F. Mosley PharmD, AAHIVP
Lillian L. Smith PharmD, MBA
Crystal K. Parke PharmD
Jamal A. Brown PharmD
A New Monotherapy for Schizophrenia and Adjunctive Therapy for Major Depressive Disorder

Brexpiprazole (Rexulti): a new monotherapy for schizophrenia and adjunctive therapy for major depressive disorder

Shannon Eaves PharmD
Jose A. Rey PharmD, BCPP

Dulaglutide (Trulicity): the third once-weekly GLP-1 agonist for type-2 diabetes

Lillian L. Smith PharmD, CPh, MBA
Juan F. Mosley PharmD, CPh, AAHIVP
Crystal Parke PharmD
Jamal Brown PharmD

Paliperidone palmitate three-month injection (Invega Trinza): the first four-times-a-year, long-acting injectable antipsychotic agent for schizophrenia

Noor Daghistani PharmD
Jose A. Rey PharmD, BCPP
Newly Approved Treatment Option for Chronic Weight Management in Obese Adults

Naltrexone/bupropion ER (Contrave): newly approved treatment option for chronic weight management in obese adults

Matthew M. Sherman PharmD
Sinziana Ungureanu PharmD Candidate
Jose A. Rey PharmD, BCPP
Once-Daily Combination Therapy for the Maintenance of COPD

Tiotropium bromide/olodaterol (Stiolto Respimat): once-daily combination therapy for the maintenance of COPD

Juan F. Mosley PharmD, CPh, AAHIVP
Lillian L. Smith PharmD, CPh, MBA
Brittany N. Dutton

Alirocumab (Praluent): first in the new class of PCSK9 inhibitors

Marina Manniello PharmD Candidate
Michele Pisano PharmD, CGP

Ivabradine (Corlanor) for heart failure: the first selective and specific If inhibitor

Sally Tse PharmD Candidate
Nissa Mazzola PharmD, CDE
A New Inhaled Insulin for the Management Of Type-1 or Type-2 Diabetes Mellitus

Afrezza (insulin human) inhalation powder: a new inhaled insulin for the management of type-1 or type-2 diabetes mellitus

Tamara Goldberg PharmD, BCPS
Elaine Wong PharmD, BCPS

Edoxaban (Savaysa): A factor Xa inhibitor

Lewey Chan
Michele Pisano PharmD, CGP

Apremilast (Otezla): A new oral treatment for adults with psoriasis and psoriatic arthritis

Tina Zerilli PharmD
Eric Ocheretyaner PharmD
A Breakthrough Treatment for Gastric Cancer

Ramucirumab (Cyramza): A breakthrough treatment for gastric cancer

Amrita D. Singh
Sapna Parmar PharmD, BCOP
Adam Pennoyer PharmD
Mary Barna Bridgeman PharmD, BCPS, CGP

Improving Options for Hepatitis C Virus Infection

Diana Gritsenko
Gregory Hughes PharmD, BCPS, CGP
A Novel Agent for the Treatment of Moderate-to-Severe Vasomotor Symptoms Associated With Menopause And the Prevention of Postmenopausal Osteoporosis

Conjugated estrogens/bazedoxifene (Duavee): a novel agent for the treatment of moderate-to-severe vasomotor symptoms associated with menopause and the prevention of postmenopausal osteoporosis

Tamara Goldberg PharmD, BCPS
Brooke Fidler PharmD
First Recombinant C1 Esterase Inhibitor for the Treatment Of Acute Attacks in Patients With Hereditary Angioedema

Conestat alfa (Ruconest): first recombinant C1 esterase inhibitor for the treatment of acute attacks in patients with hereditary angioedema

Martin Paspe Cruz PharmD, CGP, BCPP, FASCP
Vortioxetine (Brintellix): a new serotonergic antidepressant
Andrew D’Agostino
Clayton D. English PharmD, BCPP
Jose A. Rey MS, PharmD, BCPP

Ceftolozane/tazobactam: a new option in the treatment of complicated gram-negative infections

Maria Sorbera PharmD
Elizabeth Chung PharmD
Christopher W. Ho PharmD, BCACP

Riociguat (Adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Diana Khaybullina PharmD
Ami Patel PharmD
Tina Zerilli PharmD

Edoxaban: an investigational factor Xa inhibitor

Gregory J. Hughes PharmD, BCPS, CGP
Olga Hilas PharmD, MPH, BCPS, CGP, FASCP
A New and Innovative Formulation of An Antipsychotic Treatment for Agitation

Loxapine inhalation powder (Adasuve): an innovative formulation of an antipsychotic treatment for agitation

Jose Valdes PharmD
Travis Shipley
Jose A. Rey MS, PharmD, BCPP
A Second-Generation Oxazolidinone to Treat Acute Bacterial Skin and Skin Structure Infections

Tedizolid phosphate: a second-generation oxazolidinone for acute bacterial skin and skin structure infections

Elaine Wong PharmD, BCPS
Saba Rab PharmD, BCPS
Ibrutinib (Imbruvica): a novel targeted therapy for chronic lymphocytic leukemia
Sapna Parmar PharmD
Khilna Patel PharmD
Javier Pinilla-Ibarz MD, PhD

Sofosbuvir: A new oral oncedaily agent for the treatment of hepatitis C virus infection

Agnes Cha PharmD, AAHIVP, BCACP
Aliaksandr Budovich PharmD

Suvorexant, a dual orexin receptor antagonist for the management of insomnia

Tiffany Bennett
David Bray
Michael W. Neville PharmD, BCPS, FASHP

Alogliptin (Nesina) for adults with type-2 diabetes

Laura Dineen
Connie Law
Rebecca Scher
A Novel Antisense Oligonucleotide Inhibitor for the Management of Homozygous Familial Hypercholesterolemia

Mipomersen (Kynamro) for homozygous familial hypercholesterolemia

Elaine Wong PharmD, BCPS
Tamara Goldberg PharmD, BCPS
A Novel Agent for the Treatment of Actinic Keratoses
Ingenol mebutate gel (Picato) for actinic keratoses
Brooke Fidler PharmD
Tamara Goldberg PharmD, BCPS
Glucarpidase (Voraxaze) for methotrexate toxicity
Mohammad A. Rattu PharmD
Neal Shah PharmD
Jessica M. Lee PharmD
Canagliflozin (Invokana) for type-2 diabetes
Sheila Sarnoski-Brocavich BS, MS, PharmD, BCACP, CGP
Olga Hilas PharmD, MPH, BCPS, CGP
Recombinant relaxin (serelaxin), a breakthrough therapy for acute heart failure
Marta A. Miyares PharmD, BCPS (AQ Cardiology)
Kyle A. Davis PharmD, BCPS
A Selective Serotonin 5-HT2C Agonist In the Treatment of Obesity
Ashley Gustafson PharmD
Camille King PharmD
Jose A. Rey PharmD, BCPP
Phentermine/topiramate extended-release capsules (Qsymia) for weight loss
David J. Lonneman
Jose A. Rey MS, PharmD, BCPP
Brian D. McKee PharmD
A Long-Acting Anticholinergic for the Management Of Chronic Obstructive Pulmonary Disease
Aclidinium bromide inhalation powder (Tudorza) for COPD
Michele Pisano PharmD
Nissa Mazzola PharmD, CGP, CDE
A Condition of Involuntary Crying or Laughing
Dextromethorphan/quinidine (nuedexta) for pseudobulbar affect
Martin Paspe Cruz PharmD, CGP, BCPP

Apixaban (eliquis) for treating and preventing thromboembolic disease

Aliaksandr Budovich
Olga Zargarova
Anna Nogid BS, PharmD, BCPS
Linaclotide (Linzess) for irritable bowel syndrome with constipation and for chronic idiopathic constipation
Rachel Hutchins Thomas PharmD, MS
Kyle Allmond
Bapineuzumab for Alzheimer’s disease
Farah Khorassani PharmD, BCPS
Olga Hilas PharmD, MPH, BCPS, CGP
Tamara Goldberg PharmD, BCPS
Evangelina Berrios-Colon PharmD, MPH, BCPS, CACP
Vismodegib (Erivedge) for advanced basal cell carcinoma
Chris Fellner
Ticagrelor (Brilinta) for acute coronary syndrome
RaeAnne Fuller PharmD
Benjamin Chavez PharmD, BCPP
Serious Side Effects and a Hefty Price Tag May Limit Its Use

Ipilimumab (Yervoy) for metastatic melanoma

Chris Fellner
A Novel Agent for Metastatic Castration-Resistant Prostate Cancer
Cabazitaxel (Jevtana) for metastatic castration-resistant prostate cancer
Ginah Nightingale PharmD, BCOP
Jae Ryu PharmD, BCOP, BCPS
A Clinical Review
Fospropofol disodium (Lusedra) for anesthesia sedation
Ramy Boules PharmD
Andrew Szkiladz PharmD
Anna Nogid BS, PharmD, BCPS
A Breakthrough Therapy for Systemic Lupus Erythematosus
Raymond Lamore PharmD
Sapna Parmar PharmD
Khilna Patel PharmD Candidate
A Novel Phosphodiesterase-4 Inhibitor for the Treatment Of Severe Chronic Obstructive Pulmonary Disease
Jordan Baye PharmD, MA
Rachel M. Slaton PharmD, BCPS
Danielle L. Cruthirds PhD
A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder
Martin Paspe Cruz PharmD, CGP, BCPP
The Eighth Angiotensin II Receptor Blocker
Jocelyn D. Jones PharmD, BCPS
Sylvia H. Jackson PharmD, MEd, CDE
Carmen Agboton PharmD
Younos Abdulsattar PharmD, BCPS
Theologia Ternas PharmD
Danielle Garcia PharmD
A Selective Progesterone Receptor Modulator For Emergency Contraception
Andrea Kim PharmD Candidate
Mary Barna Bridgeman PharmD, BCPS
A New Approach to Weight Loss in Obese Adults
Tehane Ornellas PharmD Candidate
Benjamin Chavez PharmD, BCPP
The First Immunotherapy Agent (Vaccine) For Hormone-Refractory Prostate Cancer
Enock Anassi MD, PharmD
Uche Anadu Ndefo PharmD, BCPS
Polina Plotkin PharmD
Khusbu Patel PharmD
Amy Uminski PharmD