Over Half of Patients Had Reduced Pain Levels of 30% or More
Spina Bifida, Cleft Lip Among Defects Caused by Antiepilectics
Study Data Indicate Drug May Provide Complete Remission in PV
Teplizumab Slows Progression to Disease by at Least Two 2 Years
Over 25% of Study Patients Showed 6–12 Months Remission
Researchers Extend Previous Data, Find Association is Reversed
First Anti-PD-1 Therapy Demonstrates Improved Overall Survival
New Test Could Prevent Short- and Long-term Complications
Nivolumab/Chemotherapy Arm Shows No Unexpected Toxicities

P&T June 2019
Table of Contents


CMS and ONC Proposals Would Implement Cures Act
Since the introduction of the 2009 HITECH Act, how has system-wide data sharing fared among hospitals and physician offices? Not that well, according to the CMS. But will the new proposed rules improve things for providers, system developers, and patients?
Patient adherence to antipsychotic medications is associated with their adherence to concurrently used medications for other serious mental illnesses, T2D, and hypertension. This study suggests that using digital technology to measure adherence more accurately could provide additional information that will help providers and payers predict patient adherence to other medications.
In patients undergoing laparoscopic cholecystectomy, replacing intravenous acetaminophen with preoperative oral acetaminophen can easily be implemented in ambulatory surgery centers. This results in substantial cost savings, with few differences in pain or consumption of rescue opioids among patients in post-anesthesia care units.
Meeting HIghlights

We cover key sessions on hepatitis B, C, and D virus infections, hepatocellular carcinoma, nonalcoholic steatohepatitis, acute hepatic porphyria, and liver growth in polycystic kidney disease.


Medication Errors
Implementing IT in medication-use systems reduces adverse drug events by decreasing human error. But over-reliance on technology can lead to automation bias and complacency.
Prescription: Washington
Several drug-price “remedy” bills are floating around Congress, with most being described as a “first step.” So why is no one referring to that step as significant?
Approvals, new indications and formulations, and safety issues
Sunosi (solriamfetol) tablets for excessive daytime sleepiness with narcolepsy or obstructive sleep apnea; Zulresso (brexanolone) injection for postpartum depression in adults; Mayzent (siponimod) tablets for adults with relapsing forms of MS.

Industry announcements