BREAKING NEWS

COMPASS Trial Shows 24% Reduction in Major CV Events
Only 18.7% of Patients Treated Had Uveitis Recurrence
Protein Organizes and Stores DNA for B Cells in Methodical Fashion
Patients’ Bodies Most Common Source of Hospital-Acquired Bloodstream Infections
Growing opioid crisis fueling suicide increase according to study
Vaccine Prevents Some Cancers, Diseases Caused by 9 HPV Types
In Future, Providers May Screen for APOE4 Before Treatment 
MIT Professor Working to Produce Thousands of Drugs on Demand
Agency Scrutinizes Attempts to Block Generics
Other Means Required to Measure Effectiveness of Expensive New Therapies 

P&T October 2018
Table of Contents

Features

Most Actions Face Political, Legal, and Technical Roadblocks
President Donald Trump’s wide-ranging Blueprint to Lower Drug Prices and Reduce Out-of-Pocket Costs has implications for P&T committees, PBMs, drug manufacturers, insurers, and of course, patients. As with everything else involving health care, it’s complicated.
Due to limited retrospective data, the use of enoxaparin in specialty populations—including those with renal dysfunction, extremes of body weight, pregnant patients and pediatric patients–has not been studied in clinical trials. The authors discuss the challenges in predicting the pharmacokinetics of enoxaparin dosing in these patients and the difficulty in obtaining antiXa levels in hospitalized patients.
Pipeline Plus
The landscape of migraine therapy is set to change with the introduction of new classes of medications aimed at providing options for patients who have not responded to previous therapies. However, the pricing of the new agents will likely be a key determinant in the extent of their use in clinical practice.
Meeting Highlights
We review sessions on large-scale aspirin and anticoagulation trials, weight loss therapies, fish oil, gout, endocarditis, and cardiomyopathy, with important implications for health care providers.

Departments

Medication Errors
Part 2 of a 3-part series discusses medication safety risks related to labeling, patient education, and medication storage.
Prescription: Washington
The FDA has made it easier for P&T committees to make formulary coverage decisions by expanding the health care economics information that drug manufacturers can provide to them.
New Drugs/Drug News
Approvals, new indications, regulatory activities, and more
Ivosidenib (Tibsovo) for acute myeloid leukemia; elagolix (Orilissa) for endometriosis; and mogamulizumab-kpkc (Poteligeo) for mycosis fungoides or Sézary syndrome
Drug Forecast
Naldemedine (Symproic) for opioid-induced constipation