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Global Acute Decompensated Heart Failure (ADHF) Markets 2019: Disease Background, Treatment, Epidemiology, Marketed Drugs, Pipleine, Deals, Revenues & Landscape

DUBLIN, June 27, 2019 /PRNewswire/ -- The "Market Spotlight: Acute Decompensated Heart Failure (ADHF)" report has been added to ResearchAndMarkets.com's offering.

This Market Spotlight report covers the Acute Decompensated Heart Failure (ADHF) market, comprising key marketed and pipeline drugs, recent events and analyst opinion, clinical trials, probability of success, epidemiology information, licensing and asset acquisition deals, and drug-specific revenues.

Key Takeaways

  • Approved drugs in the acute decompensated heart failure (ADHF) space target natriuretic peptide receptors, phosphodiesterase 3, potassium channels, and troponin-C. The majority of approved therapies are administered via the intravenous route, with one drug also being available in an oral formulation.
  • Therapies in active clinical development for ADHF are spread evenly across Phase I and Phase II. Therapies in development for ADHF focus on targets such as Na-K-Cl cotransporter, corticotropin releasing factor - receptor2, guanylate cyclase, ryanodine receptor, sarcoplasmic reticulum Ca2+ -ATPase, natriuretic peptide receptors, vasopressin receptors, and phosphodiesterase 9. These therapies are administered via the oral, intravenous, and subcutaneous routes.
  • The overall likelihood of approval of a Phase I ADHF asset is 1.8%, and the average probability a drug advances from Phase III is 28.6%. Drugs, on average, take 12.9 years from Phase I to approval, compared to 9.7 years in the overall cardiovascular space.
  • There have been only two licensing and asset acquisition deals involving ADHF drugs during 2014-19. The $2,075m acquisition of Cardioxyl by Bristol-Myers Squibb in 2015, which also gave the company full rights to Cardioxyl's lead asset CXL-1427, a novel nitroxyl (HNO) donor (prodrug) in Phase II clinical development as an intravenous treatment for ADHF, was the largest deal.
  • The distribution of clinical trials across Phase I-IV indicates that the majority of trials for ADHF have been in the early and midphases of development, with 57% of trials in Phase I-II, and 43% in Phase III-IV.
  • The majority of industry-sponsored clinical trials have been completed. Adrenomed has one planned trial in the ADHF space.
  • Bayer leads industry sponsors with the highest number of clinical trials for ADHF, followed by Scios.

Key Topics Covered:

OVERVIEW

KEY TAKEAWAYS

DISEASE BACKGROUND
Definition
Symptoms
Patient subtypes
Risk factors
Diagnosis

TREATMENT
Diuretics
Vasodilator therapy
Ultrafiltration (UF)
Inotropes
Natriuretic peptides
Vasopressors/Beta blockers/ACE inhibitors
Circulatory assist devices
Other therapies

EPIDEMIOLOGY
ADHF incidence

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION
Entresto for ADHF (November 11, 2018)
PROBABILITY OF SUCCESS

LICENSING AND ASSET ACQUISITION DEALS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE
Sponsors by status
Sponsors by phase

BIBLIOGRAPHY
Prescription information

APPENDIX

For more information about this report visit https://www.researchandmarkets.com/r/u8hb5r

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SOURCE Research and Markets