- Clinical Trials
- Research News
- Industry Trends
- Agency Actions
- Drug Safety Issues
- Approvals, Launches, & New Indications
- Health Care Reform
Study: Extra Vitamin D Doesn’t Lower High Blood Pressure
No benefit seen in elderly patients with isolated systolic hypertension (August 14)
Vitamin D supplements don’t appear to reduce hypertension in older people with low vitamin D levels, according to a new study published in JAMA Internal Medicine. Previous research had linked low vitamin D levels to hypertension, heart disease, and even early death.
Researchers in the U.K. conducted a double-blind, placebo-controlled randomized study to determine whether high-dose, intermittent cholecalciferol supplementation lowers blood pressure in older patients with isolated systolic hypertension. The study involved 159 participants with a mean age of 77 years. The participants received a total of 100,000 U of oral cholecalciferol or matching placebo every 3 months for 1 year.
No significant treatment effect was seen for mean office blood pressure (–1/–2 mm Hg at 3 months and +1/0 mm Hg overall treatment effect). Moreover, no significant treatment effect was evident for any of the secondary outcomes (24-hour blood pressure, arterial stiffness, endothelial function, cholesterol level, glucose level, and walking distance).
The authors concluded that vitamin D supplementation did not improve blood pressure or markers of vascular health in older patients with isolated systolic hypertension.