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Features

Perspective
A Look Back at the Last Decade and a Look Forward to 2020
Changes related to market forces, regulatory initiatives, and the Affordable Care Act have significantly altered the traditional work of P&T committees. Redefined issues of quality, cost, and access will become even more important in the coming years.
Perspective
Drug therapy aids most epilepsy patients, but unmet challenges include drug-resistant epilepsy, adverse reactions, drug interactions, the need to better identify epileptic syndromes, and a lack of agents to prevent epilepsy and its comorbidities.
Pipeline Plus
The epilepsy market’s $4.2 billion in global sales in 2012 is expected to increase to $5.4 billion by 2022. In a market crowded with products, pharmaceutical companies have shifted their focus to devising safe adjunctive therapies for refractory patients.
Meeting Highlights
In these two major cardiology meetings, the pharmacology emphasis was strong on balancing risks of stroke and bleeding in treating heart attacks and atrial fibrillation.
Book Review
In his exhaustively researched new book, Generic: The Unbranding of Modern Medicine, physician-historian Jeremy A. Greene, MD, PhD, explores the rise of generic drugs in the U.S. and our evolving understanding of “generic equivalence.”

Departments

Medication Errors
Measuring mix-ups blamed for overdoses of insulin
Prescription: Washington
Is the Bar Being Set Too High, or Too Low?
FDA draft guidance on 503B compounding widely faulted
FDA approvals, drug indications, and updates
Naltrexone/bupropion (Contrave) for weight management; pembrolizumab (Keytruda) for melanoma; dolutegravir/abacavir/lamivudine (Triumeq) for HIV-1; and immune globulin infusion 10% (human) with recombinant human hyaluronidase (Hyqvia) for primary immunodeficiency
Drug Forecast
Riociguat (Adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

P&T TV

From Sovaldi to Ebola: A Wide-ranging Interview with Dr. David Nash

A leading authority on population health, Dr. David Nash is optimistic about the future of disruptive innovation to improve healthcare in the U.S. The interview was conducted by P&T Editor Sonja Sherritze.

Interview