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March 2015

Features

Pharmacovigilance Forum
A potassium deficiency can impair metabolic functions, and medications cause hypokalemia through a variety of mechanisms. The authors report on a 58-year-old female suffering from fatigue and weakness after a recent diagnosis of adrenal insufficiency.
The number of cancer medications approved by the Food and Drug Administration has risen steadily in recent years. This article provides a concise overview of drugs and indications added to the cancer armamentarium in 2014 and to date in 2015.
Efforts are under way to convince the U.S. Department of Labor to require more transparency from pharmacy benefit managers, which divulge few details of their financial arrangements to their customers.
A strident debate has been surging in the interventional cardiology community over the triumvirate of efficacy, safety, and cost of bivalirudin compared with heparin for anticoagulation of patients with ST-segment elevation myocardial infarction.
Pipeline Plus
Major depressive disorder is complex and poorly understood; myriad drugs target numerous mechanisms of action. By 2023, sales are expected to reach $7.6 billion.

Departments

Medication Errors
Interruptions and distractions can sidetrack patient safety.
Prescription: Washington
As first biosimilar approval nears, key questions remain.
FDA approvals, drug indications, and updates
Drug Forecast
Conjugated estrogens/bazedoxifene (Duavee): a novel agent for the treatment of moderate-to-severe vasomotor symptoms associated with menopause and the prevention of postmenopausal osteoporosis