P&T COMMUNITY
 
MediMedia Managed Markets
Our
Other
Journal
Managed Care magazine
Login / Register
Join Us  Facebook  Twitter  Linked In
 

 

 

Men With Belly Fat at Risk for Osteoporosis

Researchers link higher visceral and total abdominal fat to bone strength (Nov. 28)

Visceral, or deep-belly, obesity is a risk factor for bone loss and decreased bone strength in men, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA). “It is important for men to be aware that excess belly fat is not only a risk factor for heart disease and diabetes, it is also a risk factor for bone loss,” said Miriam Bredella, MD, associate professor of radiology at Harvard Medical School in Boston.

According to the National Center for Health Statistics, more than 37 million American men over the age of 20 are obese. Obesity is associated with many health problems, including cardiovascular diseases, diabetes, high cholesterol, asthma, sleep apnea, and joint diseases. And yet, despite all the health issues, it was commonly accepted that men with increased body weight were at lower risk for bone loss.

“Most studies on osteoporosis have focused on women. Men were thought to be relatively protected against bone loss, especially obese men,” Bredella said.

But not all body fat is the same. Subcutaneous fat lies just below the skin, and visceral or intra-abdominal fat is located deep under the muscle tissue in the abdominal cavity. Genetics, diet, and exercise are all contributors to the level of visceral fat that is stored in the body. Excess visceral fat is considered particularly dangerous, because in previous studies it has been associated with an increased risk for heart disease. After the Osteoporotic Fractures in Men study (a multicenter observational study designed to determine the risk factors for osteoporosis ) indicated that male obesity was associated with fracture risk, the researchers wanted to quantify belly fat and study its impact on bone strength.

Bredella and her team evaluated 35 obese men with a mean age of 34 years and a mean body mass index (BMI) of 36.5. The men underwent CT scans of the abdomen and thigh to assess fat and muscle mass, as well as a high-resolution CT scan of the forearm and a technique called finite element analysis (FEA) to assess bone strength and to predict fracture risk.

“FEA is a technique that is frequently used in mechanical engineering to determine the strength of materials for the design of bridges or airplanes, among other things,” Bredella said. “FEA can determine where a structure will bend or break and the amount of force necessary to make the material break. We can now use FEA to determine the strength or force necessary to make a bone break.”

In the study, the FEA analysis showed that men with higher visceral and total abdominal fat had a lower failure load and stiffness –– two measures of bone strength –– compared with men with less visceral and abdominal fat. No association was found between age or total BMI and bone mechanical properties.

The results also showed that muscle mass was positively associated with bone strength.

Source: RSNA; November 28, 2012.

More stories